Dysregulated FXR-FGF19 Signaling and Choline Metabolism is Associated with Gut Dysbiosis and Hyperplasia in a Novel Pig Model of Pediatric NASH.

To investigate the role of bile acids (BA) in the pathogenesis of diet-induced non-alcoholic steatohepatitis (NASH), we fed a "Western-style diet" (HFF) enriched with fructose, cholesterol and satu...