Apelinin Kardiyovasküler Fonksiyonlar Üzerine Etkileri The Effects of Apelin on the Cardiovascular Functions

Apelin, the endogenous ligand of the APJ receptor, has been expressed in a variety of tissues, including adipose tissue, stomach, heart, lung, testis, ovary, mammary glands, brain, liver, skeletal muscle, and kidney. Apelin is secreted as a pre-proprotein of 77 amino acids, with a signal peptide in the N-terminal region. After translocation into the endoplasmic reticulum and cleavage of the signal peptide, it becomes a proprotein consisting of 55 amino acids. It may generate several active fragments such as apelin 36, apelin 17, apelin 13. Although their effect and function there is still unclear, apelin signalling may have an important role in the physiopathology of diseases such as hypertension, heart failure, cardiovascular disease, type 2 diabetes, obesite. In the future apelin can be used as a protective and therapeutic agent and make an important contribution to human health and economic sense.