Formation of Isoxazoles Using Cerium Ammonium Nitrate (CAN): A One-Pot Synthesis of Glycomimetics

1,3-Dipolar cycloaddition reactions of carbohydrate dipolarophiles with cerium(IV) ammonium nitrate CAN(IV) in acetone, acetophenone, or pinacolone yielded the corresponding 3,5-disubstituted isoxazoles, stable pharmacophores for glycomimetic syntheses.