Study on the vertical transmission of Y chromosome microdeletions from father to son
2007
OBJECTIVE: To analyze the Y chromosome microdeletions in the family of the infertile male and to study on the vertical transmission of Y chromosome microdeletions from father to son. METHODS: The peripheral blood of infertile patients' family male members was extracted and analyzed with modified multiplex PCR. The infertile family tree was drawn according to the results. RESULTS: Two cases in twelve investigated families had azoospermia factor (AZFc) microdeletion heredity. The others had no heredity. CONCLUSION: AZFc microdeletion of the Y chromosome can be transmitted to the male offspring naturally,and the same deletion can result in different phenotypes in different individuals.
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