Novel Associations Between Brca1 Variants C.181 T>G (Rs28897672) and Ovarian Cancer Risk in Saudi Females

Background Mutations in BRCA1 gene have been implicated in ovarian cancers, and BRCA testing may be conducted in high-risk women. This study was designed to determine the frequency of three single nucleotide polymorphisms (SNPs) variants in BRCA1 gene and BRCA1 expression in Saudi females with ovarian cancer.