Predictors of growth response to growth hormone in otherwise normal short children.

Sixty prepubertal short children (39 boys) with heights less than 2 SD for age and gender were treated daily for 1 year with recombinant human growth hormone (GH), either 0.1 IU/kg (group 0.1, n=32) or 0.05 IU/kg (group 0.05, n=28). Reserve of GH was determined by at least one GH provocative stimulus and 24-hour continuous blood withdrawal to determine the integrated concentration of GH (IC-GH). All participants had a GH response to provocative tests >10 μ g/L. The height velocity (mean±SD) of the group as a whole increased from 4.46±1.02 to 7.59±1.65 cm/yr ( p p