THE MECHANICAL FACTORS INFLUENCING THE ASSESSMENT OF INTERMEDIATE STENOSIS SEVERITY EXPLAINED THROUGH FRACTIONAL FLOW RESERVE

Assessment of intermediate coronary lesions with diameter stenosis of 40% to 70% severity is being a challenge for cardiologist to identify potentially ischemic stenosis for revascularization and nonculprit stenosis which can be deferred from stenting. An invasive coronary angiography and intravascular ultrasound provide anatomic information of stenosis severity whereas an invasive fractional flow reserve index (FFR) provides the functional significance of the stenosis severity. The measurement of functional significance of stenosis severity minimizes the procedural complications such as coronary dissection, in stent restenosis etc. rather than anatomical significance measure. The FFR cutoff value of ≤0.8 is used to distinguish ischemic and nonischemic stenosis. The FFR is clinically well validated even though it is influenced by the mechanical factors such as hyperemic flow and guide wire insertion. In recent times, noninvasive coronary computed tomography (CCTA) modality has become popular in the diagno...