Cardiopulmonary function during 5 hours of constant‐dose isoflurane in laterally recumbent, spontaneously breathing horses

Steffey, E.P., Hodgson, D.S., Dunlop, C.I., Miller, M.F., Woliner, M.J., Heath, R.B. & Grandy, J. Cardiopulmonary function during 5 hours of constant-dose isoflurane in laterally recumbent, spontaneously breathing horses. J. vet. Pharmacol. Therap. 10, 290–297. Hemodynamic and respiratory effects of 5 h of unvarying 1.57%, end-tidal (1.2 MAC) isoflurane in O2 anesthesia were characterized in ten left laterally recumbent horses. Compared to base line values at 30 min of constant dose isoflurane, cardiac output, hematocrit, total plasma solids, PaC02, and peak inspired gas flow progressively and significantly (P < 0.05) increased over the course of study. Arterial blood pressure increased (P < 0.05) during the first 2 h of constant dose of isoflurane then decreased and remained near base line values. Inspiratory time progressively decreased with time of anesthesia. All horses recovered from anesthesia uneventfully within 1 h of termination of isoflurane.