Differential regulation of vasopressin gene expression in the hypothalamus of endotoxin-treated 14-day-old rat

Abstract The E. coli endotoxin 0111 B4, a lipopolysaccharide (LPS), in a dose of 200 ng kg body weight/50 μl artificial cerebrospinal fluid (CSF) was given intracisternally to 14-day-old rats. Four hours later CSF, blood and urine were sampled, and consecutive brain sections from the hypothalamic area of the brain were prepared for in situ hybridization. The LPS treatment resulted in a significant (p + and K + concentrations, glucose level, pH, bicarbonate or PaCO 2 , PaO 2 values. LPS injection, however, resulted in a significantly (p