FORMULATION AND COMPARITIVE OPTIMIZATION OF MULTIPLE LIPID DRUG CARRIERS OF VALSARTAN FOR ORAL CONTROLLED RELEASE

In the present study, an attempt was made to formulate, comparatively evaluate and optimize multiple lipid drug carriers of valsartan for oral controlled release. Two lipid drug delivery systems i.e. Niosomes and Liposomes were studied for the delivery of the anti-hypertensive drug valsartan. They were formulated as suspensions.Ether injection and rotary evaporator method were chosen for the formulation of physically and chemically stable niosomes and liposomes of valsartan.In-vitro evaluation studies for the prepared multiple drug delivery carriers of valsartan were performed. The in-vitro evaluation studies performed were evaluation for physical appearance, particle size by scanning electron microscopy (SEM), drug content , entrapment efficiency and in-vitro drug release. Optimization of the best lipid drug delivery system and the best method of preparation was done based on the results of In-Vitro drug release and entrapment efficiency values. Finally, an attempt was made to improve the bioavailabilty of the administered drug, reduce side effects and improve patient compliance by optimizing the best formulation through lipid drug delivery technology.