Pediatric stroke: unique implications of the immature brain on injury and recovery

Abstract Pediatric stroke causes significant morbidity for children resulting in lifelong neurological disability. Although hyperacute recanalization therapies are available for pediatric patients, most patients are ineligible for these treatments. Therefore, the mainstay for pediatric stroke treatment relies on rehabilitation to improve outcomes. Little is known about ideal rehabilitation therapies for pediatric stroke patients and the unique interplay between the developing brain and our models of stroke recovery. In this review, we first discuss the consequences pediatric stroke. Second, we examine the scientific evidence that exists between the mechanisms of recovery and how they are different in the pediatric developing brain. Finally, we evaluate potential interventions that could improve outcomes.