A Review of Clinical Manifestations of Gangrene in Western Uganda

Gangrene is primarily caused by diminished or total loss of blood supply to body tissues that leads to cell death. The compromised blood supply may result from trauma, serious injury, surgery, infection or chronic vascular diseases and immunosuppression. Other risk factors include diabetes mellitus, human immunodeficiency virus infection, long term smoking, alcoholism, malignancies, liver and renal diseases [Czymek et al., 2009]. Multiple digital gangrene has been reported to result from traditional therapy [Unuigbe et al., 2009].