Synthesis of Trifluoromethylated Tetrasubstituted Allenes via Palladium-Catalyzed Carbene Transfer Reaction

Chao Pei,Zhen Yang,Rene M. Koenigs

Synthesis of Trifluoromethylated Tetrasubstituted Allenes via Palladium-Catalyzed Carbene Transfer Reaction

2020

Chao Pei
Zhen Yang
Rene M. Koenigs

Herein, we report on the palladium-catalyzed synthesis of trifluoromethylated, tetrasubstituted allenes from vinyl bromides and trifluoromethylated diazoalkanes in good to excellent yield. This rea...

Keywords:

Chemistry
Oxidative addition
Catalysis
Indene
Allene
Vinyl bromide
Carbene
Palladium
Medicinal chemistry
Reductive elimination

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