Advances of long non-coding RNA UCA1 in cancers

Long non-coding RNA urothelial carcinoma associated 1 (UCA1) is initially discovered and named in bladder cancer tissue, which is highly expressed in multi types of tumor tissues, such as bladder cancer, ovarian cancer, lung cancer, suggesting that UCA1 acts as oncogene. UCA1 is confirmed to regulate tumor cell proliferation, apoptosis, invasion and migration, which plays an important role in the occurrence and development of cancers. UCA1 is expected to become a new biomarker for diagnosis, prognosis and drug susceptibility, which may be a promising therapeutic target of cancer. Key words: Neoplasms; Proto-oncogenes; Urothelial carcinoma associated 1