Hypoglycemia in chick embryos infected with S. typhosa via the allantoic cavity.

SummaryS. typhosa strains Ty 2 and Vi I grew at the same rate when inoculated into the allantoic cavity of 10-day chick embryos, reaching concentrations of 109 viables per ml within 16 hours. Although Ty 2 in small inocula produced a fatal infection in more embryos, comparable numbers of Vi I also killed a significant proportion of the embryos within similar intervals. Both strains produced marked hypoglycemia in 10-day embryos after 16 hours although the yolksac glycogen levels were not reduced. Embryos 16 days old were more resistant to fatal infection; in these, normal blood glucose levels were maintained. Hypoglycemia did not appear to be due to extensive systemic invasion of the embryo by S. typhosa.