Stereoselective Diels—Alder Reactions Promoted under Continuous-Flow Conditions by Silica-Supported Chiral Organocatalysts

A simple HPLC column filled with silica-supported MacMillian catalyst works as a catalytic reactor for the Diels—Alder reaction between cyclopentadiene and cinnamic aldehyde affording the cycloadducts in high yields and enantioselectivities.