[Effect of honey-toasting on the constituents and contents of aristolochic acid analogues in aristolochiae fructus].

Objective: To evaluate the degree of de-toxification of Aristolochiae Fructus by honey-toasting technology from chemical viewpoint.Methods: The contents of aristolochic acid analogues(AAs) in Aristolochiae Fructus and its honey-toasted product were determined by HPLC,and the degree of de-toxicfication was evaluated comprehensively.Results: After honey-toasted,the contents of AAs decreased to varying degrees,and some new compounds were found.Conclusion: The constituents and contents of Aristolochiae Fructus change after honey-toasted,which indicate honey-toasting can reduce the toxicity of Aristolochiae Fructus.