Initial kinetics and cumulative biodistribution of Tc-99m-diethyl IDA in a mammalian animal model

The early kinetic behavior and cumulative biodistribution of Tc-99m-N-..cap alpha..-(2,6-diethyl acetanalide) iminodiacetic acid have been described in a mammalian (rabbit) model as a basis for dosimetric considerations of this hepatobiliary agent. These data were obtained from in vivo region of interest time activity curves generated by automated data processing techniques from the initial distribution and localization of the radiopharmaceutical. Subsequently, using classic biodistribution techniques, tissue analysis of the percentage of administered dose per tissue or organ was determined.