Effects of intracoronary magnetized stent placement on level changes of NO, ET-1 and SOD in coronary sinus of patients with coronary heart disease

Objectives Our study aimed to investigate the effects of magnetized stent on serum NO, plasma ET-1 and superoxide dismutase (SOD) in coronary sinus in patients undergoing PTCA and ICSP. Methods All 39 patients had angiographically significant coronary artery disease, which was over 75 percent diameter stenosis of at least one epicardial artery. According to the types of stents implanted, the patients were devided into two groups: non-magnetized stent(NMS)and magnetized stent(MS)groups. Blood samples were collected during the first 6 hours after PTCA and ICSP to determine the above variables. Results Serum levels of NO and SOD of MS group were significantly higher than those of NMS, while plasma levels of ET-1 didn' t change as markedly as those of NMS. Conclusions (1)MS reduced the release of ET-1 during PTCA and the synthesis after ICSP.(2)MS increased the speed and amount of NO production after ICSP. (3)MS promoted the activities of SOD significantly in favor of removing ROI and thus contributed to reducing I/R injury after ICSP.