A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor
1995
Abstract A novel series of arylpiperazines has been synthesised which show high affinity for dopamine D 3 receptors. Several of these compounds exhibit ca . 100 fold selectivity for the dopamine D 3 receptor over D 1 , D 2 and D 4 receptors. In vivo studies suggest that 4 (GR103691) may have an atypical antipsychotic profile.
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