The radiation response of cultured mammalian V79-S171 cells exposed to a wide concentration range of sulphate salt solutions.

SummaryThe radiation response of Chinese hamster cells (V79) exposed to a wide concentration range of Li2SO4, Na2SO4 or K2SO4 has been examined and compared with the radiation response of cells treated in an identical manner with LiCl, NaCl, or KCl solutions. At hypotonic salt concentrations, cells were radiosensitized by both the chloride and sulphate salts. At high salt concentrations, approximately greater than 0·9 M, a radioprotective effect was observed with both chloride and sulphate salts. At intermediate salt concentrations from about 0·2 to 0·9 M, the cells that were treated with the sulphate salt solutions were radioprotected; cells treated with chloride salt solutions were radiosensitized. The difference in radiation response was attributed to the difference in anions for the two types of salts used.