ИССЛЕДОВАНИЕ ВОЗМОЖНОСТИ ИСПОЛЬЗОВАНИЯ КОЛЛОИДНЫХ КВАНТОВЫХ ТОЧЕК НА ОСНОВЕ AgInS2 /ZnS ДЛЯ ФЛУОРЕСЦЕНТНОГО ИМИДЖИНГА В СРАВНЕНИИ С ФЛУОРОФОРАМИ, ЗАКРЕПЛЕННЫМИ НА ПОВЕРХНОСТИ НАНОЧАСТИЦ

The paper investigated the fluorescence of two fluorescent dyes — fluorescein and indocyanine green bonded with magnetite and silica nanoparticles in comparison with colloidal quantum dots of nanocrystals of AgInS2 / ZnS in vitro on a fluorescent imager IVIS Lumina LT Series III. Studies showed that quantum dots have sufficient luminous efficiency, in comparison with fluorescent dyes, for this type of diagnosis. The effect of quenching of fluorescence in the mixture with blood was observed, which makes impossible the usage of colloidal quantum dots QD for in vivo diagnosis without the shell. The study of hemodynamics with intravenous injection of colloidal quantum dots in laboratory animals showed no changes in the heart rate. A decrease in mean arterial pressure with subsequent recovery to normal was discovered, which requires more detailed study.