Hydoglucemic imidazoline compounds.

THE PRESENT INVENTION REFERS TO CERTAIN NEW IMIDAZOLINE COMPOUNDS AND THEIR ANALOGS, FOR USE FOR THE TREATMENT OF DIABETES, DIABETIC COMPLICATIONS, METABOLIC DISORDERS OR RELATED DISEASES IN WHICH THERE IS AN ALTERATION TO THE EVACUATIONS, PHARMACEUTICS THAT UNDERSTAND AND THE PROCEDURES FOR THEIR PREPARATION. THE COMPOUNDS HAVE THE FOLLOWING FORMULA: IN WHICH: X IS -O-, -S-, OR -NR5 -, R5 IS HYDROGEN, RENT C1-8, OR AN AMINO PROTECTIVE GROUP; R1, R2, R3 ARE, INDEPENDENTLY, HYDROGEN OR C1-8 RENT; R 1 AND R 2 OPTIONALLY AND JOINTLY A LINK AND R 1 '' AND R 3 ARE, INDEPENDENTLY, HYDROGEN OR RENT C1-8; R1 AND R2 COMBINE OR PTATIVELY TOGETHER WITH THE CARBON ATOMS TO WHICH THEY ARE COUPLED TO FORM A C3-7 AND R1 '' AND R3 CARBOCICLIC RING ARE, INDEPENDENTLY, HYDROGEN OR C1-8 RENT; R1 AND R1 '', TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE COUPLED ARE OPTIONALLY COMBINED TO FORM A C3-7 SPI-CARBON RING, AND R2 AND R3 ARE INDEPENDENTLY, HYDROGEN OR C1-8 RENT; R2 AND R3, TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE COUPLED, ARE OPTIONALLY COMBINED TO FORM A SPIROCARBOCYCLE RING C 3-7 AND R 1 AND R 1 '' ARE, INDEPENDENT E, HYDROGEN OR RENT C1-8; N ES 0, 1 OR 2; M ES 0, 1 OR 2; M '' IS 0, 1 OR 2; Q '' ES 0, 1, 2, 3, 4 O5; R4 ES AND ES -O-, -S-, OR -NR6 -; Y '' ES -0- O -S-; R6 AND R7 ARE, INDEPENDENTLY, HYDROGEN, C1-8 RENT, C3-7 CYCLALKYL, C1-8 ALCOXI, C1-8 RENT, C1-8 RENT, HALO, C1-8 SULFINYL RENT, C1-8, C7- CX, C7-8, ARIL-ALCOXI C1-8, HALO, HALO- ALQUILO C1-8, HALO- ALCOXI C18, NITRO, NR10 R11, -CON R10 R11, ARILOALQUILO C1-8, OPTIONALLY SUBSTITUTED, OPTIONALLY SUBSTITUTED, OPTIONALLY SUBSTITUTED HALO-SUBSTITUTED, CYANO, HYDROXY, COR12, HALO-C1-8-ALQUILSULFINILO, OR C1-8 HALOALQUILSULFONILO, OR ALCOXIALQUILO OF FORMULA: IN WHICH P IS 0,1, 2, 3 OR 4; AND Q IS 1, 2, 3, 4, OR 5; R12 IS C1-8 RENT OR OPTIONALLY REPLACED PHENYL; R8 IS HYDROGEN, RENT C1-8, HALOALQUILO C1-8), OPTIONALLY REPLACED PHENYL, OPTIONALLY REPLACED HETEROCICLYL, COO-RENT C1-8, CO-ARYL OPTIONALLY REPLACED, CO-RENT C1-8, SO2 C1-8, SO2 C1-8, SO2 C1-8, SO2 C1-8, SO2 C1-8, SO2 C1-8, SO2 C1-8, SO2 C1-8, SO2 C1-8, SO2 C1-8, SO2 C1-8, SO2 C1-8 OPTIONALLY REPLACED, PHENYL-RENT C1-8 OPTIONALLY REPLACED, CH3 ((CH2) P) -O (CH2) 1 -O-; R9 IS HYDROGEN, HALO, C1-8 RENT, C1-8 HALO-ALKYL, C1-8 ALQUIL RENT, C1-8 RENT-HALO, C3-7 CYCLALKYL, OPTICALLY SUBSTITUTED CYLLOCYL, C3- C3-7- OPTIONALLY REPLACED ARILOXI, OPTIONALLY REPLACED HETEROARILOXI, OR ARILO OR OPTIONALLY REPLACED HETEROARILO, C3-7 CYCALALKYL, C3-7 CYCLALKYLENE, C3-7 CYCLE, RHYO-C116, C -106 ORCYLL-C106 OCILLYL .