15(p-[123I]Iodophenyl)penadecanoic acid as tracer of lipid metabolism: comparison with [1-14C]palmitic acid in murine tissues

Received Aug. 22, 1983;revisionaccepted July 13, 1984. For reprints contact: Dr. Sven N. Reske, Institut Clin. Exp. Nuclear Medicine, UniversitAt Bonn, Sigmund-Freud-Str. 25, 5300 Bonn 1, West Germany. regarded as a reference tracer for evaluation of free fatty-acid metabolism (13). A dual-tracer approach was chosen in order to establish intermediary tracer con version in an identical metabolic environment. Tissue uptake of both tracers was compared in heart, lung, liver, kidneys, and spleen in order to analyze tracer metabolism in tissues with highly variable free-fatty-acid metabolic rates (20). A pulse-chase-like experimental approach was used to evaluate I-PPA and PA tissue uptake ki netics and their subsequent metabolic conversion.