Synthesis of tetrasubstituted cyclopentadienes via palladium-catalyzed reaction of (Z)-2-en-4-yn acetates and N-methyl indoles.

An efficient approach for the synthesis of tetrasubstituted cyclopentadienes through Pd-catalyzed reactions of (Z)-2-en-4-yn acetates with substituted indoles was developed. This methodology has the advantages of broad scope, simple conditions and easily accessible starting materials.