Prognostic value of miR-196, IDO, and AXL in patients (p) with localized gastrointestinal stromal tumors (GIST).

10553 Background: GIST is the most common gastrointestinal sarcoma. Miettinen criteria (Mc) define the risk of recurrence. Overexpression of miR-196 has been associated with high risk of relapse, metastasis and poor survival. Overexpression of AXL and IDO have been related to resistance to imatinib mesilate (IM). To date, the prognostic value of these molecular markers has not been examined. Methods: We retrospectively reviewed 40 p with localized GIST diagnosed between 2003 and 2012 in a single institution. Clinical and pathological variables and the expression levels of miR-196, AXL and IDO were correlated with outcome. Results: 52.5% of p were female; mean age was 59.3 years. GISTs were located mainly in the stomach (50%) and small intestine (42.5%). 67.5% were spindle cell tumors; 70% had <5 mitoses per 50 high-power fields. Risk of relapse was high for 45% of p. The capsule was broken in 5 p, and resection was incomplete in 2. cKIT mutations were present in exon 9 in 17.5% of p and in exon 11 in 62.5...