Congenital disturbances of vascular genesis

The study of the congenital disturbances of vascular genesis began one 100 years ago (Hochstetter-1891; Lewis-1905). The growth factors and the integrines play an important part in these disturbances and influence the 3 stages of tumoral angiogenesis (21): first stage: stimulation induced by growth factors; second stage: proliferation with invasion; third stage: maturation stimulated by integrines.