Экспериментальное изучение токсичности препарата на основе полиакрилата золота

Toxicological study of the parent substance of a potential antitumor drug – gold polyacrylate (Aurumacryl) – belonging to the new class of polymeric gold containing compounds was performed in experiments on BDF 1 inbreed mice. Acute and subchronic toxicity was evaluated under single and multiple intraperitoneal injections of the drug. Parameters of the acute toxicity of Aurumacryl were the same for males and females of mice (LD 50 = 100 mg/kg). The absence of drug accumulation as a result of long-term (28 days) treatment by Aurumacryl at a total dose of 1272 mg/kg was observed for the test mice (both males and females). After 42 days of experiment, the maximum average body weight loss in drug-treated males and females was 13 and 17%, respectively, in comparison to intact control animals. It was established that potential targets of the toxic action of Aurumacryl were the spleen (for both males and females) and kidneys (for males), since the weights of these organs increased more than two times ( p ≤ 0.01) in comparison to the intact control. Thus, it has been found that Aurumacryl belongs to drugs of the 3rd class of toxicity.