Study of the first antibacterial agent pipemidic acid modifying Keggin polyoxometalate

Abstract A new compound based on polyoxometalates (POMs) and the quinolone antibacterial pipemidic acid (HPPA), {[Co(PPA) 2 ]H 2 [ SiW 12 O 40 ]}·HPPA·3H 2 O ( 1 ), has been prepared and characterized by elemental analyses, IR and singe crystal X-ray diffraction. The title compound represents the first example of POMs modified by the quinolone antibacterial HPPA, in which the POMs are modified by [Co(HPPA) 2 ] subunits. Its antitumor activity on MCF-7 cells was investigated by the. The results show that the title compound exhibits higher antitumor activity than its parent, which indicates that introduction of M-PPA into the POM surface can increase their antitumor activity and make the compounds to penetrate into the cells easily.