Clinical applications of dynamic optical tomography in vascular disease

Vascular disease is a significant source of mortality and morbidity for many patient populations. While substantial strides in surgical therapeutics have been made in the past decade, our limited understanding of the microvascular processes, which are invisible to conventional imaging modalities and beyond the scope of our current physiologic paradigms, has slowed the advancement of medical therapeutic interventions. In this report we present data in support of an emerging body of work demonstrating that the method of dynamic optical tomography can yield critical insights into the underpinnings of microvascular pathophysiology in large tissue structures.