A9684 Comparing anti-fibrotic effects of the irap inhibitor, hfi-419 to an angiotensin receptor blocker and ace inhibitor in a high salt-induced mouse model of kidney disease

Objectives:To compare the anti-fibrotic effects of the IRAP inhibitor, HFI-419 to the AT1 receptor blocker, Candesartan cilexetil (CAND) or ACE inhibitor, Perindopril (PERIN) in a murine high salt (HS) diet-induced model of kidney disease.Methods:8–10 week male C57Bl/6J mice were subjected to 8-week