Manganese-Catalyzed Hydroarylation of Unactivated Alkenes.

: Transition-metal-catalyzed hydroarylation of unactivated alkenes with strategic use of remote coordinating functional groups has received significant attentions recently in order to address the issues of both low reactivity and poor selectivity. A bidentate 8-aminoquinoline amide group is the most successfully adopted in unactivated alkenes for Pd- and Ni-catalysis. Herein, we describe the first manganese-catalyzed hydroarylation of unactivated alkenes bearing diverse simple functionalities with arylboronic acids. A series of δ- and γ-arylated amides, ketones, pyridines, and amines was accessed with excellent regioselectivity and in high yields. Hydroalkenylation of unactivated alkenes was also proved nicely applicable under this manganese-catalysis regime. The protocol features earth-abundant manganese catalysis, easily available substrates, diverse functional group tolerance, and excellent regioselective control.