The chronobiological aspects of changes in the level of serum immunoglobulins in healthy people

: The results of the determination of the concentration of immunoglobulins (Ig) in the blood of 540 donors, carried out at the period of 1989-1990, are analyzed. The presence of annual biorhythms in the content of IgA, IgG and IgM has been established, the biorhythmic curves of IgG and IgM practically coinciding and the biorhythmic curve of IgA shifting with respect to the curves of IgG and IgM by about 3 months. As revealed by this analysis, a decrease in the concentration of IgG and IgM correlates with an increase in the occurrence of purulent septic infections after surgical interventions. The presence of annual rhythms in the content serum should be considered in the interpretation of the results of immunological studies, as well as in planning and realization of different therapeutic and prophylactic measures.