Synthesis and antibacterial activity of 1-alkoxyalkyl-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones

Reactions of methyl ethers of acylpyruvic acids with a mixture of aromatic aldehyde and 2-methoxyethylamine or 3-isopropoxypropylamine were used to synthesize a series of 1-alcoxyalkyl-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones possessing antibacterial activity.