Studies toward the synthesis of (−)-stenine
2015
Abstract Herein is described an application of the acyl nitroso type 2 intramolecular Diels–Alder reaction as a key step in the progress toward the total synthesis of the Stemona alkaloid (−)-stenine. The chiral cycloaddition precursor is rapidly assembled from a cyclohexene intermediate synthesized through an asymmetric, organocatalyzed Robinson annulation. A key selective alkene reduction provides a tricyclic intermediate which could prove useful in the synthesis of the titular natural product.
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