Isotope labeled sodium cyclamate and preparation method thereof

The invention discloses isotope labeled sodium cyclamate and a preparation method thereof. The sodium cyclamate is sodium cyclamate labeled by isotopic deuterium. The chemical structural formula is as follows, wherein X is H or D. The preparation method of the sodium cyclamate comprises the following steps: by taking cyclohexanone as a raw material, firstly, carrying out H-D exchange on heavy water and cyclohexanone to obtain tetradeuterated cyclohexanone; then, reducing and ammoniating to obtain tetradeuterated cyclohexylamine or pentadeuterated cyclohexylamine; and then sulfonating and alkalizing to obtain sodium cyclamate. The isotope abundance of the isotope labeled sodium cyclamate reaches over 99% which fully meets the demands of detection reagents. The method is simple in synthetic process and cheap in price of raw material and the synthesized product has the advantages of high product purity, low production cost and the like, and is easy to separate and purify. The isotope labeled sodium cyclamate has good economical efficiency and using value.