The novel approaches towards fluoroalkyl-containing heteroannulated pyrimidines

The review is focused on the synthesis of fluoroalkyl-containing heteroannulated pyrimidines via the reactions of alkyl 3-oxo-3-polyfluoroalkylpropionates and their ethoxymethylidene and 2-arylmethylidene derivatives with hetarylamines. Heteroannulation of polyfluoroalkyl-containing pyrimidines is also discussed.