Level of IFN-gamma and lnterleukin-10 ln Tuberculosis Rat Models After Administration ofCentell asiatica Extract

Evidence based of centello asiatica as immunomodulator in tuberculosis diseases are unclear Therefore, the further research of centello asiatica as immunomodulator are necessary, through measuring the level of IFN-gamma and lnterleukin-10. Twenty eight male rats infected with Mycoboctetium tuberculosis through intratrachea. After 29 days post infection, rats were divided randomly into four groups.Groups 1,2,and 3 were groups that obtained the ethanol extract of centello asiatica at 375 mg / kgBW, 75O mg /kgBW and l5OO mg / kgBW, during 14 days, per oral and fourth group was the control group that obtained only vehicle. The measurement of IFN-gamma and lnterleukin-10 level were performed by ELISA on the day 15th . The results have shown that the highest mean level of IFN-gamma and The lowest mean level of lnterleukin-10 is the group that obtained the ethanol extract of Centella asiatica at l50 mg / kgBW. ln conclusion, the ethanol extract of Centello osiotico improve immune response of tuberculosis rat models, through increased IFN gamma level