Method for compounding pioglitazone hydrochloride controlled-release pellet preparation

The invention discloses a method for compounding a pioglitazone hydrochloride controlled-release pellet preparation. A pioglitazone hydrochloride controlled-release pellet is composed of three parts, namely a blank pellet core, a drug-containing layer and a controlled-release layer, wherein the drug-containing layer is composed of pioglitazone hydrochloride, a binder and a solubilizer; the controlled-release layer is composed of a controlled-release material and a pore-foaming agent. The compound metformin hydrochloride-pioglitazone hydrochloride controlled-release pellet preparation, which is formed by mixing the pioglitazone hydrochloride controlled-release pellet with a metformin hydrochloride controlled-release pellet, has an ideal effect of regulating blood sugar level, is capable of reducing the toxic and side effects of drugs and achieving a continuous and stable blood sugar level reduction effect in vivo, is advantageous for improving the compliance of a patient, has high bioavailability and stable blood concentration, and is capable of effectively improving the clinical curative effect, and therefore, good dosage regimens and curative effects are provided for domestic and overseas diabetics.