An observational study to validate the Satisfaction Measure of the Injection of Growth Hormone Therapy (SMIGHTy) questionnaire

AbstractObjective:The objective of this study was to psychometrically evaluate a tool to measure adult caregivers’ level of satisfaction with the delivery device used to administer injections of recombinant human growth hormone (rhGH) to a child – the Satisfaction Measure of the Injection of Growth Hormone Therapy (SMIGHTy *SMIGHTy is a trademark of Genentech, Inc., South San Francisco, CA, USA.) questionnaire.Research design and methods:One hundred caregivers who administer rhGH to a child using an injection device completed the SMIGHTy questionnaire at baseline and 7–14 days later, and also completed other measures of treatment adherence and treatment satisfaction at baseline.Main outcome measures:SMIGHTy reliability (inter-item and test–retest) and external validity (association with other study measures) were assessed.Results:Analyses revealed good inter-item agreement and test–retest reliability for the SMIGHTy questionnaire. External validity, measured by associations with adherence and other measur...