Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma

Sonja Eberth,Björn Schneider,Andreas Rosenwald,Elena Hartmann,Julia Romani,Margarete Zaborski,Reiner Siebert,Hans G. Drexler,Hilmar Quentmeier

Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma

2010

Sonja Eberth
Björn Schneider
Andreas Rosenwald
Elena Hartmann
Julia Romani
Margarete Zaborski
Reiner Siebert
Hans G. Drexler
Hilmar Quentmeier

Background Epigenetic inactivation of tumor suppressor genes (TSG) by promoter CpG island hypermethylation is a hallmark of cancer. To assay its extent in human lymphoma, methylation of 24 TSG was analyzed in lymphoma-derived cell lines as well as in patient samples.

Keywords:

Cancer research
Lymphoma
Diffuse large B-cell lymphoma
Bisulfite sequencing
Follicular lymphoma
DNA methylation
Mantle cell lymphoma
Anaplastic large-cell lymphoma
Tumor suppressor gene
Molecular biology
Biology
CpG site
Cancer
Epigenetics

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