Mechanism of Obesity Formation in SR-AI/II Deficient Mice on High-Fat Diet

Objective To explore the possible mechanism of obesity formation in SR-AⅠ/Ⅱgene knock-out mice.Methods SR-AⅠ/Ⅱ gene knock-out mice(KO)and wild type control mice(WT)were fed with normal chow control(CHOW)and high fat diet(HFD)to observe the effects of high fat diet on KO.Results The experimental diet promoted a significant increase in animal body weight over the 12-wk period.The body weight of KO-HFD were higher significantly than KO-CHOW and WT-HFD(P0.05);TC、TG、LDL-C、HDL-C of KO-HFD were higher significantly than WT-HFD(P0.01).Plasma glucose levels of KO-CHOW and KO-HFD were higher significantly than WT-CHOW and WT-HFD(P0.01).Plasma leptin and TNF-α levels of KO-HFD significantly increased than KO-CHOW(P0.01).Conclusion SR-AⅠ/Ⅱ can affect serum lipid and glucose levels in mice.SR-AⅠ/Ⅱ deficient mice may due to reduction of leptin sensitivity.