Comparison between different bone treatments on areal bone mineral density (aBMD) and bone microarchitectural texture as assessed by the trabecular bone score (TBS).

Abstract Purpose The objective of the study was to assess longitudinal effects of different osteoporosis treatments on TBS and aBMD at lumbar spine. Method We analyzed 390 patients (men: 72; women: 318; age > 40 years; mean follow-up of 20 months and BMI  2 ). We stratified the cohort by treatments: Naive of treatment (Naive, n = 67), Calcium and Vitamin D (CaVitD, n = 87), Testosterone (Te, n = 36), Alendronate (AL, n = 88), Risedronate (Ri, n = 39), Denosumab (Dmb, n = 43) and Teriparatide (PTH, n = 30). The follow-up changes from baseline were normalized at 24 months. Results After 24 months, Naive group TBS decreased by 3.1% (p  Conclusion As expected, TBS of Naive subjects decreased with age. As expected a TBS preservation has been observed under AL and Ri. Te and CaVitD effects on TBS were evaluated for the first time: a similar preservation effect has been observed. A significant TBS increase was observed under Denosumab and PTH. TBS could be a useful tool to monitor treatment effects.