Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.

Alan M. Warshawsky,Charles A. Alt,Joseph T. Brozinick,Allen R. Harkness,Eric Hawkins,James Robert Henry,Donald P. Matthews,Anne Reifel Miller,Elizabeth A. Misener,Chahrzad Montrose-Rafizadeh,Gary A. Rhodes,Quanrong Shen,Jennifer Ann Vance,Uko Effiong Udodong,Minmin Wang,Tony Y. Zhang,Richard W. Zink

Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.

2006

Alan M. Warshawsky
Charles A. Alt
Joseph T. Brozinick
Allen R. Harkness
Eric Hawkins
James Robert Henry
Donald P. Matthews
Anne Reifel Miller
Elizabeth A. Misener
Chahrzad Montrose-Rafizadeh
Gary A. Rhodes
Quanrong Shen
Jennifer Ann Vance
Uko Effiong Udodong
Minmin Wang
Tony Y. Zhang
Richard W. Zink

PPAR ligands with varied subtype selectivity have been synthesized using an achiral aminomethyl dihydrocinnamate template. Several compounds in this series have demonstrated potent plasma glucose and triglyceride lowering capability in rodent models of type 2 diabetes.

Keywords:

Organic chemistry
Nuclear receptor
Peroxisome proliferator-activated receptor
Biochemistry
Triglyceride
Chemistry
Ligand
Stereochemistry
Selectivity
In vitro
Chirality (chemistry)
Carboxylic acid
Chemical synthesis

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