Cichorin A: a new benzo-isochromene from Cichorium intybus

One new benzo-isochromene, named cichorin A (1), together with three known compounds oleanolic acid, β-sitosterol, and β-sitosterol glucopyranoside, was isolated from Cichorium intybus. The structure of the new compound was elucidated by detailed spectroscopic analysis such as 1H, 13C NMR, COSY, HMQC, HMBC, and HR-EI-MS. Relative configuration of asymmetric centers of cichorin A (1) was determined by the analysis of the 1H NMR coupling constants together with the NOESY experiment.