N-substituted amines arilsulfonilheterociclicas as gamma-secretase inhibitors.

A compound of formula I: ** (See formula) ** or a salt and / or solvate pharmaceutically acceptable, wherein: L is -O- or -N (R6) -; R1 is selected from the group consisting of aryl substituted with one or more substituents R7 which may be the same or different, and heteroaryl substituted with one or more substituents R7 which may be the same or different; R2 is selected from the group consisting of - alkylene (C0-C6) -cycloalkylene (C3-C6) -alkylene (C0-C6) -XC (O) -Y, - alkylene (C0-C6) -cycloalkylene (C3- C6) -alkylene (C0-C6) -C (O) -Y and - cycloalkylene (C3-C6) -alkylene (C1-C6) -C (O) -Y substituted on the alkylene moiety with one or more hydroxy group; R3 is selected from the group consisting of unsubstituted aryl, aryl substituted with one or more substituents R7 which can be identical or different, unsubstituted alkyl, alkyl substituted with one or more substituents R7 which can be identical or different, unsubstituted cycloalkyl and cycloalkyl substituted with one or more substituents R7 which may be the same or different; each R4 and R5 is independently selected from the group consisting of H, and alkyl independently substituted with one or more substituents R7 which may be the same or different; R6 is selected from the group consisting of H, alkyl independently substituted with one or more substituents R7 which can be identical or different, unsubstituted aryl and aryl independently substituted with one or more substituents R7 which may be the same or different; R7 is selected from the group consisting of halo, -CF3, -OH, alkyl, alkyl substituted with 1 to 4 hydroxy groups, -O-alkyl, -OCF3, -CN, -NH (alkyl), -N (alkyl) 2, -NH (aryl), -N (aryl) 2, -N (aryl) (alkyl), -C (O) O-alkyl, -alkylene-NH (alkyl), -alkylene-N (alkyl) 2, -alkylene-NH (aryl), -alkylene-N (aryl) 2, -alkylene-N (aryl) (alkyl), - NHC (O) -alkyl, -N (alkyl) C (O) -alkyl, -N (aryl) C (O) -alkyl, -NHC (O) -aryl, -N (alkyl) C (O) -aryl, -N (aryl) C (O) -aryl, -NHC (O) -heteroaryl, -N (alkyl) C (O) -heteroaryl, -N (aryl) C (O) -heteroaryl, -NHC (O) -NH2, -NHC (O) -NH (alkyl), -NHC (O) -N (alkyl) 2, -NHC (O) -NH (aryl), -NHC (O) -N (aryl) 2, -NHC (O) -N (alkyl) (aryl), -N (alkyl) C (O ) -NH 2, -N (alkyl) C (O) -NH (alkyl), -N (alkyl) C (O) -N (alkyl) 2, -N (alkyl) C (O) -NH (aryl), -N (alkyl) C (O) -N (aryl) 2, -N (alkyl) C (O) -N (alkyl) (aryl), -N (aryl) C (O) -NH2, -N (aryl ) C (O) -NH (alkyl), -N (aryl) C (O) -N (alkyl) 2, -N (aryl) C (O) -NH (aryl), -N (aryl) C (O ) -N (aryl) 2 and -N (aryl) C (O) -N (alkyl) (aryl); each of R8 and R9 is independently selected from the group consisting of H, alkyl, cycloalkyl, arylalkyl, heteroarylalkyl, ** (See formula) ** each R10 is independently selected from the group consisting of H, -OH, alkyl alkyl groups substituted with 1 to 4 hydroxy, -O-alkyl, -O-alkyl groups substituted with 1 to 4 hydroxy, cycloalkyl, substituted cycloalkyl groups from 1 to 4 hydroxy, -C (O) O-alkyl, -alkylene-C (O) -OH, unsubstituted heterocycloalkyl, heterocycloalkyl substituted with one or more groups R7, -alkylene-C (O) -NH2, -alkylene-C (O) -NH (alkyl), -alkylene-C (O) -N (alkyl) 2, -alkylene-C (O) -NH (aryl), -alkylene-C (O) -N (aryl) 2, -alkylene-C (O) -N (alkyl) ( aryl), -C (O) -NH2, -C (O) -NH (alkyl), -C (O) -N (alkyl) 2, -C (O) -NH (aryl), -C (O) -N (aryl) 2, -C (O) -N (alkyl) (aryl), -O-cycloalkyl and -O-cycloalkyl groups substituted with 1 to 4 hydroxy; or two R10 groups together with the ring carbon atoms to which they are attached form a cycloalkyl or heterocycloalkyl ring of 4 to 7 members; or two R10 groups together with the carbon atom of the ring to which they are attached form a carbonyl group; R11 is H, alkyl, substituted alkyl groups of 1 to 4 hydroxy, cycloalkyl, substituted cycloalkyl groups of 1 to 4 hydroxy, arylalkyl, heteroarylalkyl, -C (O) O-alkyl, -C (O) -alkyl, - C (O) -alkyl wherein said alkyl moiety is substituted by one or more hydroxyl groups, -C (O) -cycloalkyl, -C (O) -NH2, -C (O) -NH (alkyl), -C (O) -N (alkyl) 2, -C (O) -NH (aryl), -C (O) -N (aryl) 2, -C (O) -N (alkyl) (aryl), -C ( O) -alkylene-NH2, -C (O) -alkylene-NH (alkyl), -C (O) -alkylene-N (alkyl) 2, -C (O) -alkylene-NH (aryl), -C ( O) -alkylene-N (aryl) 2, -C (O) -alkylene-N (alkyl) (aryl), -S (O2) -alkyl, -alkylene-C (O) -OH, alkylene-O-alkylene -OH, unsubstituted aryl, aryl independently substituted with one or more substituents R7, unsubstituted heteroaryl, heteroaryl independently substituted with one or more substituents R7, and -alkylene-C (O) O-alkyl; X is -O- or N (R6) -; Y is selected from the group consisting of -NR8R9, -N (R6) - (CH2) b-NR8R9 wherein b is an integer from 2 to 6, unsubstituted aryl, aryl independently substituted with one or more substituents R7 which may be identical or different, unsubstituted heteroaryl, heteroaryl independently substituted with one or more substituents R7 which may be the same or different, alkyl, cycloalkyl, unsubstituted arylalkyl, arylalkyl independently substituted on the aryl moiety with one or more substituents R7 which can be the same or different, arylcycloalkyl unsubstituted I arylcycloalkyl independently substituted on the aryl with one or more substituents R7 which can be identical or different, unsubstituted heteroarylalkyl, heteroarylalkyl independently substituted on the heteroaryl moiety with one or more substituents R7 which may be the same rest or different, I heteroarylcycloalkyl unsubstituted heteroarylcycloalkyl independently substituted on I re sto heteroaryl with one or more substituents R7 which can be identical or different, unsubstituted heterocycloalkyl, heterocycloalkyl independently substituted with one or more substituents R7 which can be identical or different, arylheterocycloalkyl unsubstituted and arylheterocycloalkyl independently substituted on the aryl moiety with one or more substituents R7 which may be the same or different; or Y is selected from the group consisting of: ** (See formula) ** Z is selected from the group consisting of H, -OH, -O-alkyl, unsubstituted heterocycloalkyl, heterocycloalkyl optionally independently substituted with one or more substituents R14 which may be the same or different, -NR8R9, -NR8R13, benzo-fused heterocycloalkyl and heterocycloalkyl unsubstituted benzo-condensed, optionally independently substituted on the benzo- or heterocycloalkyl moiety with one or more substituents R14 which may be the same or different; each R12 is independently H or alkyl; R13 is selected from the group consisting of H, unsubstituted heterocycloalkyl, heterocycloalkyl independently substituted with one or more substituents R14 which may be identical or different, unsubstituted arylalkyl, arylalkyl independently substituted on the aryl moiety with one or more substituents R14 which may be identical or different, unsubstituted heteroarylalkyl, heteroarylalkyl optionally independently substituted on the heteroaryl moiety with one or more substituents R14 which may be identical or different, unsubstituted cycloalkyl optionally cycloalkyl independently substituted by one or more substituents R14 which may be the same or different , -alkylene-cycloalkyl, unsubstituted -alkylene-cycloalkyl independently substituted on the cycloalkyl moiety with one or more substituents R14 which may be identical or different, unsubstituted -alkylene-heterocycloalkyl, and -alkylene-without heterocycloalkyl independently substituted in the rest heterocycloalkyl with one or more substituents R14 which may be the same or different; R14 is selected from the group consisting of halo, -CF3, -OH, -O-alkyl, -OCF3, -CN, -NR8R9, -C (O) -alkyl, -C (O) -aryl, -C ( O) -NR8R9, -C (O) O-alkyl, -alkylene-NR8R9, -alkylene-C (O) O-alkyl, -N (R8) C (O) -alkyl, -N (R8) C (O ) -aryl, -N (R8) C (O) -heteroaryl, -N (R8) C (O) -NR8R9, piperidinyl, pyrrolidinyl, aryl, heteroaryl and -O-CH2-CH2-O-, in which both oxygen atoms of said -O-CH2-CH2-O- are bound to the same carbon atom and with the proviso that aryl and heteroaryl moieties are not substituted with said-CH2-CH2-O- -O; m and n are independently 0, 1 or 2, with the proviso that m + n is 1 or 2; p is an integer of 1 to 4; r is an integer of 1 to 3; t is an integer from 0 to 2; or wherein: L is as defined above; R1 is phenyl, pyridyl or thiophenyl, each of which is substituted with one or more substituents R7; R2 is -alkylene (C1-C6) -XC (O) -Y; R3 is phenyl, ethyl, n-propyl, iso-propyl, cyclopropyl or -CH2-cyclopropyl, each of which may be unsubstituted or substituted with one or more substituents R7 which may be the same or different; R4, R5, R6, R7, R8, R9, R10, R11, X, Y, Z, R12, R13 and R14 are as defined above; m and n are each 1; p, r and t are as defined above; or wherein: L is as defined above; R1 is phenyl, pyridyl or thiophenyl, each of which is substituted with one or more substituents R7; R2 is -cycloalkylene (C3-C6) -XC (O) -Y, - cycloalkylene (C3-C6) -alkylene (C1-C6) -C (O) -Y, or - cycloalkylene (C3-C6) -alkylene ( C1-C6) -C (O) -Y substituted on the alkylene radical (C1-C6) one or more hydroxy groups; R3 is -CH2-cyclopropyl, which may be unsubstituted or substituted with one or more substituents R7 which may be the same or different; R4, R5, R6, R7, R8, R9, R10, R11, X, Y, Z, R12, R13 and R14 are as defined above; m and n are each 1; p, r and t are as defined above; or a compound or a salt and / or pharmaceutically acceptable solvate selected from the group consisting of: ** (See formula) **