The effect of recombinant tumor necrosis factor-thymosin-α1 on angiogenesis in the tumor and the effectiveness of neoadjuvant chemotherapy in locally advanced breast cancer.

1030Background: There is a few data on tumor necrosis factor drugs used in neoadjuvant treatment in locally advanced breast cancer (LABC) patients. Many studies demonstrate the importance of angiogenesis in the development of carcinomas, whereas there is a little known about the influence of recombinant protein of tumor necrosis factor-thymosin-alpha1 (TNF-T) on angiogenesis in ВС. The aim of the study was to investigate markers of angiogenesis and vascular proliferation in the tumor and to evaluate the efficacy of TNF-T in the neoadjuvant treatment of LABC. Methods: Eligibility criteria included LABC of IIB-IIIB stages, ECOG ≤ 1, adequate liver, kidney and bone marrow function, no brain metastases. Recombinant protein of TNF-T 200000 IU was used peritumorally (injected around the tumor) on D1-5 (30 min before cytostatics injection), combined with standard FAC or PA regimens. The factors of angiogenesis CD31 and CD34 were studied in trephine-biopsy specimens before treatment and in postsurgical biopsies o...