Population differences in allele frequencies at the OLR1 locus may suggest geographic disparities in cardiovascular risk events

AbstractBackground: Several studies have demonstrated a link between cardiovascular disease (CVD) susceptibility and the genetic background of populations.Endothelial activation and dysfunction induced by oxidized low-density lipoprotein (ox-LDL) is one of the key steps in the initiation of atherosclerosis. The oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1) gene is the main receptor of ox-LDL. We have previously characterized two polymorphisms (rs3736235 and rs11053646) associated with the risk for coronary artery disease (CAD) and acute myocardial infarction (AMI).Aim: Given their clinical significance, it is of interest to know the distribution of these variants in populations from different continents.Subjects and methods: A total of 1229 individuals from 17 different African, Asian and European populations was genotyped for the two considered markers.Results: The high frequencies of ancestral alleles in South-Saharan populations is concordant with the African origin of our species. T...