PKP-001 Current vancomycin dosing recommendations for paediatric patients: a pharmacokinetic evaluation

Background Current paediatric vancomycin (VANC) dose regimens recommend 40–60 mg/kg bodyweight/day in 3–4 doses, adjusted according trough values (optimum range 10–20 mg/L). Often, multiple dose escalations over several days after the start of treatment are needed to obtain appropriate levels. Purpose To evaluate the current dosing scheme (4 × 15 mg/kg) against the optimal pharmacokinetic/pharmacodynamic parameters for VANC (AUC/MIC ≥ 400) and trough levels. Material and methods Setting: a paediatric ward in a tertiary care university hospital. Patients >1 year and 12 years. Statistical analysis was done using SPSS 22.0. Results Twenty-four patients (21 haematological; median age 6.3 years) were included with 183 available trough levels. VANC clearance was correlated with total administered fluid (ρ = 0.410, p 12 years (p Conclusion Current paediatric vancomycin dose recommendations are insufficient and should take the patient’s age more into account. In order to quickly obtain appropriate levels, we propose the following daily dosing scheme: 12 years: 4 × 15 mg/kg/day. A larger prospective study will be needed to confirm the recommended paediatric vancomycin dose regimen. References and/or acknowledgements No conflict of interest.