Interrelationship Between Renal Haemodynamics, Drug Kinetics and Drug Action

The renal haemodynamics of a particular patient may affect the pharmacological and pharmacokinetic properties of various drugs. For example, diminution in renal haemodynamics may lead to fluid retention and an increase in the volume of distribution of the drug. Also, fluid retention causes a decrease in plasma protein concentration which for certain drugs can result in altered protein binding and consequently increased proportion of unbound drug and a more marked pharmacological response.